ARC Centre of Excellence in Synthetic Biology

SYNTHETIC BIOLOGY

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24, Feb 2021

The future of synthetic biology

We are now at the point when technology can allow information to flow from digital systems into living organisms and systems, and biological devices are being reimagined as advanced cyber-physical systems.

“OK, Google, do I need to wear a mask in here?”  Imagine if your personal digital assistant could identify traces of COVID-19 in a room’s air, in real time, and tell you if you needed to take precautions.  Long a staple of science fiction, “bio-informational” tools are poised to change the way we imagine, and interact with, the living world.

In a paper recently published in Nature Communications, Macquarie University’s Thom Dixon, Thomas Williams and Isak (Sakkie) Pretorius take an in-depth look at what may be coming to a biological system near you, and sooner than you might have thought.

And in thinking ahead, says Professor Pretorius, “We are also thinking about what will be needed to make sure these technologies are safe for the planet and what the legal and regulatory frameworks need to safeguard society from what the unintended consequences might be.”

One of the underpinnings of Macquarie’s research framework is consilience – a term taken from biologist E.O. Wilson’s quest for a unified theory of knowledge, spanning from physics and biology to the humanities and social sciences.

For this reason, like Macquarie’s work throughout the ARC Centre of Excellence for Synthetic Biology, this paper is multi-disciplinary, drawing on the arts and social sciences to examine, not just the technical aspects of such revolutionary technology, but the broader implications and potential risk/benefit, to make sure that when these technologies are operational, they are also fit for social and environmental purpose.

The 21st century so far has been a period in which satellites, sensors and medical devices have made remarkable advances, and collected staggering amounts of data. The key word, though, is “collected” – and collection is a one-way process. Information has flowed from the built, natural and living environment into digital systems, with nothing flowing back. But this is beginning to change.

We are now at the point when technology can allow information to flow the other way – from digital systems into living organisms and systems. With the practices and techniques of synthetic biology now being integrated into ‘multiscale’ designs that allow two-way communication across organic and inorganic information systems, biological devices are being reimagined as advanced cyber-physical systems.

Imagine, for example, that a vineyard contains one grape vine – just one – that has an engineered biosensor in its DNA. If that plant was getting low on water, it could send electrical pulses to a satellite, alerting the vineyard manager that it was time to turn the sprinklers on. This solves the problems of both under- and over-watering, optimises water use, and could also optimise yield.

The same plant could also potentially monitor air quality. If our hypothetical grape vine was in, for example, the NSW Hunter Valley, where vineyards and coal mines share the land, a sentinel plant could alert both vineyard and mine management if pollutants were escaping.

Or to take another example – what if we could use engineered gut microbiota, controlled by thought (monitored by an EEG) to release medication on time and in the correct amounts? People who are paralysed would no longer need to depend on others being there at the right time when they needed medication. Over time, this could even be integrated with wearables and smartphones, to enable more sensitive calibration of medication delivery in a far broader range of patients.

 

Thom Dixson National Research Assessments Leader, Prof Sakkie Pretorius Deputy Vice-Chancellor (Research) – Office and Thomas Williams Department of Molecular Sciences – Research . Each of these authors have an article in Nature this month.

These are technologies for which the potential is truly vast, but they might encounter resistance. As the article points out, “It remains unclear how those sectors of the public who have traditionally taken an opposition stance to engineering biology will respond to treatments and vaccines that are a product of that discipline and practice.” The consilience approach is needed to ensure that public concern is anticipated and addressed, he says.

Pretorius stresses that these technologies are not yet practicable. But, he argues, ‘We need to look 10 to 20 years ahead, so that we’re ready. By getting the legal and governance aspects right at the same time as we’re perfecting the science, we make sure we use the technology without risk of harm, because we’ve already thought that through”.